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KMID : 0892720090130020182
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Journal of the Korean Society of Maternal and Child Health
2009 Volume.13 No. 2 p.182 ~ p.194
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Association of the Level of Serum Uric Acid and Metabolic Syndrome in Middle-aged Women
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Lee Hye-Mi
Park Jung-Han
Kim Sung-Hi
Kim Jong-Yeon
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Abstract
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Objectives: Hyperuricemia is known to be a risk factor for cardiovascular disease. The variables related to metabolic syndrome(MS), as well as other cardiovascular risk factors such as serum uric acid, differ according to gender. The study was performed to assess the relationship of serum uric acid (SUA) with metabolic syndrome in middleaged healthy women and observed the patterns of those association in pre- and postmenopausal status.
Methods: The 757 women aged over 40 years who had visit for Health examination were enrolled and divided into four groups (Quartile 1:1.7~3.6 ㎎/dL, Quartile 2:3.7~4.2 ㎎/dL, Quartile 3:4.3~4.8 ㎎/dL, Quartile 4:4.9~7.6 ㎎/dL) according to their SUA level. The blood pressure, lipid profiles, fasting serum glucose, waist circumference, high sensitivity CRP and apolipoprotein were compared between the four group. The MS was defined by the modified ATP III criteria.
Results: The prevalence of MS was 16.8%. There was a positive association between SUA and component of MS excepting fasting serum glucose, respectively (p＜0.001). After adjustment for covariates, the risk of women in the highest quartile of SUA (4.9~7.6 ㎎/dL) had 2.14 (95% CI: 1.16~3.97) fold increase in risk of MS as compared with those who were in the lowest quartile (1.7~3.6 ㎎/dL). and the same patterns were observed in pre-and post menopausal status. The association between SUA and MS observed more strangely in pre-menopausal status than post-menopausal status but interaction between SUA and menopausal status was not significant.
Conclusion: Our study suggests that SUA levels were independently associated with metabolic syndrome. Although the SUA level was in the normal range, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies.
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KEYWORD
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metabolic syndrome, uric acid, woman, menopause
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